Journal article
Mass spectrometry beyond the native state
- Abstract:
- Native mass spectrometry allows the study of proteins by probing in vacuum the interactions they form in solution. It is a uniquely useful approach for structural biology and biophysics due to the high resolution of separation it affords, allowing the concomitant interrogation of multiple protein components with high mass accuracy. At its most basic, native mass spectrometry reports the mass of intact proteins and the assemblies they form in solution. However, the opportunities for more detailed characterisation are extensive, enabled by the exquisite control of ion motion that is possible in vacuum. Here we describe recent developments in mass spectrometry approaches to the structural interrogation of proteins both in, and beyond, their native state.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 5.1MB, Terms of use)
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- Publisher copy:
- 10.1016/j.cbpa.2017.11.019
Authors
- Publisher:
- Elsevier
- Journal:
- Current Opinion in Chemical Biology More from this journal
- Volume:
- 42
- Pages:
- 130-137
- Publication date:
- 2017-12-27
- Acceptance date:
- 2017-11-30
- DOI:
- EISSN:
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1879-0402
- ISSN:
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1367-5931
- Pmid:
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29288996
- Language:
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English
- Keywords:
- Pubs id:
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pubs:815331
- UUID:
-
uuid:2feee478-4b3a-4dfb-bac1-32b273f05122
- Local pid:
-
pubs:815331
- Source identifiers:
-
815331
- Deposit date:
-
2018-01-25
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2017
- Notes:
- © 2017 Elsevier Ltd. All rights reserved. This is the author accepted manuscript following peer review version of the article. The final version is available online from Elsevier at: 10.1016/j.cbpa.2017.11.019
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