Journal article
Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
- Abstract:
- γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
- Publication status:
- Published
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Authors
- Journal:
- Bioorganic and medicinal chemistry letters More from this journal
- Volume:
- 24
- Issue:
- 21
- Pages:
- 4954-4957
- Publication date:
- 2014-11-01
- DOI:
- EISSN:
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1464-3405
- ISSN:
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0960-894X
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:485362
- UUID:
-
uuid:750daacd-a6a6-40b8-8a66-fbd9d0d936cc
- Local pid:
-
pubs:485362
- Source identifiers:
-
485362
- Deposit date:
-
2014-11-16
Terms of use
- Copyright date:
- 2014
- Notes:
-
publisher: Elsevier
articletitle: Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase
journaltitle: Bioorganic and Medicinal Chemistry Letters
articlelink: http://dx.doi.org/10.1016/j.bmcl.2014.09.035
content_type: article
copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.
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