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Plasmodium falciparum and P. vivax demonstrate contrasting chloroquine resistance reversal phenotypes

Abstract:

High-grade chloroquine (CQ) resistance has emerged in both P. falciparum and P. vivax The aim of the present study was to investigate phenotypic differences of CQ resistance in both of these species and the ability of known CQ resistance reversal agents (CQRRAs) to alter CQ susceptibility.Between April 2015 and April 2016, the potential of verapamil (VP), mibefradil (MF), L703,606 (L7), and primaquine (PQ) to reverse CQ resistance was assessed in 46 P. falciparum and 34 P. vivax clinical isol...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/AAC.00355-17

Authors


Wirjanata, G More by this author
Handayuni, I More by this author
Prayoga, P More by this author
Leonardo, L More by this author
Apriyanti, D More by this author
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Swiss National Science Foundation More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
61
Issue:
8
Pages:
e00355-17
Publication date:
2017-05-22
Acceptance date:
2017-05-08
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:698052
URN:
uri:fffc51e4-7204-44dd-b3e8-fb4999cba386
UUID:
uuid:fffc51e4-7204-44dd-b3e8-fb4999cba386
Local pid:
pubs:698052

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