Journal article icon

Journal article

Articular cartilage injury rapidly activates TAK1 in chondrocytes by inducing its phosphorylation and K63-polyubiquitination

Abstract:

Objectives Mechanical injury to cartilage predisposes to osteoarthritis (OA). Wounding the articular cartilage surface causes rapid activation of MAP kinases and NFκB mimicking the response to inflammatory cytokines. Here, we identify the upstream signalling mechanisms involved. Methods Cartilage was injured by dissecting it from the articular surface of porcine metacarpophalangeal joints (MCP) or by avulsing murine proximal femoral epiphyses. Protein phosphorylation was assayed by Western bl...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1002/art.39965

Authors


More by this author
Department:
Oxford, MSD, NDORMS, KIR
Didangelos, A More by this author
More by this author
Department:
Oxford, MSD, NDORMS, KIR
More by this author
Department:
Oxford, MSD, NDORMS, KIR
More from this funder
Funding agency for:
Vincent, TL
Kennedy Trust More from this funder
Publisher:
Eiley Publisher's website
Journal:
Arthritis and Rheumatology Journal website
Volume:
69
Issue:
3
Pages:
565–575
Publication date:
2017
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Pubs id:
pubs:653573
URN:
uri:ffebb346-b849-40e1-a4ca-7fa8a53dfe53
UUID:
uuid:ffebb346-b849-40e1-a4ca-7fa8a53dfe53
Local pid:
pubs:653573
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP