Polyomavirus early region alternative poly(A) site: 3'-end heterogeneity and altered splicing pattern.

Journal article

The position of an alternative polyadenylation [poly(A)] site at the 3' end of the polyomavirus middle T antigen (T-Ag) coding sequences suggests the possibility of a functional role for this site in early gene regulation. The fine structure of this alternative poly(A) site was determined by cDNA sequence and 3' S1 analyses. Cleavage-poly(A) was found to be heterogeneous, occurring at multiple CA dinucleotides downstream from the AATAAA signal sequence. About 50% of the alternative poly(A) ta...

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Authors: Norbury, C; Fried, M

• Publication status: Published
• Journal: Journal of virology
• Volume: 61
• Issue: 12
• Pages: 3754-3758
• Publication date: 1987-12-01
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Protein Biosynthesis; Animals; RNA, Viral; Fibroblasts; Transcription, Genetic; Nucleic Acid Hybridization; Cell Line, Transformed; Base Sequence; Poly A; Antigens, Polyomavirus Transforming; Gene Expression Regulation; RNA Splicing; Polyomavirus; RNA, Messenger; Genes, Viral; Cell Line