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Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

Abstract:

Inactivation of the von Hippel-Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the alpha subunits of hypoxia-inducible factor (HIF), constitutive upregulation of the HIF complex, and overexpression of HIF target genes. However, recent studies have indicated that in this setting, upregulation of the closely related HIF-alpha isoforms, HIF-1alpha and HIF-2alpha, have contrasting effects on tumour growth, and activate distinct sets of target g...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6603675

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Role:
Author
Journal:
British journal of cancer
Volume:
96
Issue:
8
Pages:
1284-1292
Publication date:
2007-04-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:ffd4e42f-87e5-4965-b21e-ce1e5fd7f285
Source identifiers:
25688
Local pid:
pubs:25688

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