Journal article icon

Journal article

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.

Abstract:

A single-domain fragment, cAb-HuL22, of a camelid heavy-chain antibody specific for the active site of human lysozyme has been generated, and its effects on the properties of the I56T and D67H amyloidogenic variants of human lysozyme, which are associated with a form of systemic amyloidosis, have been investigated by a wide range of biophysical techniques. Pulse-labeling hydrogen-deuterium exchange experiments monitored by mass spectrometry reveal that binding of the antibody fragment strongl...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/bi8005797

Authors


Expand authors...
Journal:
Biochemistry
Volume:
47
Issue:
42
Pages:
11041-11054
Publication date:
2008-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:ffb78650-a956-44ca-b44a-b7510c648cb5
Source identifiers:
59318
Local pid:
pubs:59318

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP