Functional regulation of p73 and p63: development and cancer.

Journal article

The transcription factor and tumour suppressor p53 and its two homologues p63 and p73 form a family of proteins. p63 and p73 show much greater molecular complexity than p53 because they are expressed both as multiple alternatively spliced C-terminal isoforms, and as N-terminally deleted, dominant-negative proteins that show reciprocal functional regulation. In addition, several other factors, such as post-translational modifications and specific and common family regulatory proteins, result o...

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Authors: Melino, G; Lu, X; Gasco, M; Crook, T; Knight, R

• Publication status: Published
• Journal: Trends in biochemical sciences
• Volume: 28
• Issue: 12
• Pages: 663-670
• Publication date: 2003-12-01
• DOI: 10.1016/j.tibs.2003.10.004
• ISSN: 0968-0004
• Language: English
• Keywords: Protein Binding; Humans; Tumor Suppressor Protein p53; Nuclear Proteins; Mutation; Genes, Tumor Suppressor; Trans-Activators; Cell Cycle; Cell Cycle Proteins; Phosphoproteins; Animals; Apoptosis; Binding Sites; DNA-Binding Proteins; Tumor Suppressor Proteins; Transcription Factors; Models, Biological; Neoplasms