Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards.

Journal article

The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker of bone formation (serum procollagen type I N propeptide, s-PINP) and a marker of bone resorption (serum C-terminal telopeptide of type I collagen, s-CTX) are used as reference analytes for bone turnover markers in clinical studies.

Authors: Vasikaran, S; Eastell, R; Bruyère, O; Foldes, A; Garnero, P

• Journal: Osteoporos Int
• Volume: 22
• Issue: 2
• Pages: 391-420
• Publication date: 2011-02-01
• DOI: 10.1007/s00198-010-1501-1
• EISSN: 1433-2965
• ISSN: 0937-941X
• Language: English
• Keywords: Osteoporotic Fractures; Adult; Treatment Outcome; Biological Markers; Aged; Aged, 80 and over; Reference Standards; Female; Male; Osteoporosis, Postmenopausal; Bone Density; Risk Assessment; Algorithms; Bone Remodeling; Middle Aged; Humans; Osteoporosis