- Abstract:
-
Weight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with -759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine a potential association of two functional polymorphisms of the promoter region of this gene: -759C/T (rs3813929) and -697G/C (rs518147), with weight gain after 6 weeks of olanzapine monotherapy. It included 107 patients with schizophrenia; among them 36 are first-episode drug...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/tpj.2009.18
-
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- Journal:
- The pharmacogenomics journal
- Volume:
- 9
- Issue:
- 4
- Pages:
- 234-241
- Publication date:
- 2009-08-05
- DOI:
- EISSN:
-
1473-1150
- ISSN:
-
1470-269X
- URN:
-
uuid:ff969add-5782-4cd6-ab54-1f3535c7e663
- Source identifiers:
-
186226
- Local pid:
- pubs:186226
- Copyright date:
- 2009
Journal article
Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.
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