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Journal article

Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.

Abstract:

Weight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with -759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine a potential association of two functional polymorphisms of the promoter region of this gene: -759C/T (rs3813929) and -697G/C (rs518147), with weight gain after 6 weeks of olanzapine monotherapy. It included 107 patients with schizophrenia; among them 36 are first-episode drug...

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Publication status:
Published

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Publisher copy:
10.1038/tpj.2009.18

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
The pharmacogenomics journal
Volume:
9
Issue:
4
Pages:
234-241
Publication date:
2009-08-05
DOI:
EISSN:
1473-1150
ISSN:
1470-269X
URN:
uuid:ff969add-5782-4cd6-ab54-1f3535c7e663
Source identifiers:
186226
Local pid:
pubs:186226

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