Delamination of cells from neurogenic placodes does not involve an epithelial-to-mesenchymal transition.

Journal article

Neurogenic placodes are specialized regions of embryonic ectoderm that generate the majority of the neurons of the cranial sensory ganglia. Here we examine in chick the mechanism underlying the delamination of cells from the epibranchial placodal ectoderm. We show that the placodal epithelium has a distinctive morphology, reflecting a change in cell shape, and is associated with a breach in the underlying basal lamina. Placodal cell delamination is distinct from neural crest cell delamination...

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Authors: Graham, A; Blentic, A; Duque, S; Begbie, J

• Publication status: Published
• Journal: Development (Cambridge, England)
• Volume: 134
• Issue: 23
• Pages: 4141-4145
• Publication date: 2007-12-01
• DOI: 10.1242/dev.02886
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: rhoB GTP-Binding Protein; In Situ Hybridization; Electroporation; Ovum; Nervous System; DNA-Binding Proteins; Ectoderm; Animals; Transcription Factors; Chick Embryo; Ganglia, Sensory; Gene Expression Regulation, Developmental; Microscopy, Electron; Neurons; Epithelial Cells; Female; Genes, Reporter; Cell Differentiation; Mesoderm