Cell biology of membrane trafficking in human disease.

Journal article

Understanding the molecular and cellular mechanisms underlying membrane traffic pathways is crucial to the treatment and cure of human disease. Various human diseases caused by changes in cellular homeostasis arise through a single gene mutation(s) resulting in compromised membrane trafficking. Many pathogenic agents such as viruses, bacteria, or parasites have evolved mechanisms to subvert the host cell response to infection, or have hijacked cellular mechanisms to proliferate and ensure pat...

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Authors: Howell, G; Holloway, Z; Cobbold, C; Monaco, A; Ponnambalam, S

• Publication status: Published
• Journal: International review of cytology
• Volume: 252
• Pages: 1-69
• Publication date: 2006-01-01
• DOI: 10.1016/s0074-7696(06)52005-4
• ISSN: 0074-7696
• Language: English
• Keywords: Humans; Genetic Diseases, Inborn; Golgi Apparatus; Cell Physiological Phenomena; Endoplasmic Reticulum; Biological Transport; Exocytosis; trans-Golgi Network; Genetic Therapy; Cytoskeleton; Endocytosis; Membrane Proteins; Cell Membrane; Signal Transduction; Lysosomes; Animals