Biosynthesis of cryptic lipopolysaccharide glycoforms in Haemophilus influenzae involves a mechanism similar to that required for O-antigen synthesis.

Journal article

It is generally thought that mucosal bacterial pathogens of the genera Haemophilus, Neisseria, and Moraxella elaborate lipopolysaccharide (LPS) that is fundamentally different from that of enteric organisms that express O-specific polysaccharide side chains. Haemophilus influenzae elaborates short-chain LPS that has a role in the pathogenesis of H. influenzae infections. We show that the synthesis of LPS in this organism can no longer be as clearly distinguished from that in other gram-negati...

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Authors: Hood, D; Randle, G; Cox, A; Makepeace, K; Li, J

• Publication status: Published
• Journal: Journal of bacteriology
• Volume: 186
• Issue: 21
• Pages: 7429-7439
• Publication date: 2004-11-01
• DOI: 10.1128/jb.186.21.7429-7439.2004
• EISSN: 1098-5530
• ISSN: 0021-9193
• Language: English
• Keywords: Humans; Gene Expression Regulation, Bacterial; Carbohydrate Sequence; N-Acetylneuraminic Acid; Haemophilus influenzae; Mass Spectrometry; Genes, Bacterial; O Antigens; Lipopolysaccharides; Mice; Molecular Sequence Data; Bacterial Proteins; Animals