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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Abstract:

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin levels adjusted for BMI, lower HDL cholesterol levels and higher triglyceride levels) and provide evidence that their link with higher cardiometabolic risk is underpinned by an association with lower adipose mass in peri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ng.3714

Authors


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Funding agency for:
van de Bunt, M
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Funding agency for:
McCarthy, M
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Grant:
MC_UU_12015/1, MC_PC_13046, MC_PC_13048 and MR/L00002/1
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Issue:
1
Pages:
17–26
Publication date:
2016-11-14
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:659550
URN:
uri:ff69ecd0-0cad-4898-841b-95fa5722dc04
UUID:
uuid:ff69ecd0-0cad-4898-841b-95fa5722dc04
Local pid:
pubs:659550
Language:
English
Keywords:

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