Passive control of quorum sensing: prevention of Pseudomonas aeruginosa biofilm formation by imprinted polymers.

Journal article

Here we present the first molecular imprinted polymer (MIP) that is able to attenuate the biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa through specific sequestration of its signal molecule N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C(12)-AHL). The MIP was rationally designed using computational modeling, and its capacity and specificity and that of a corresponding blank polymer toward signal molecule of P. aeruginosa (3-oxo-C(12)-AHL) and its analogue were...

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Authors: Piletska, E; Stavroulakis, G; Larcombe, L; Whitcombe, M; Sharma, A

• Journal: Biomacromolecules
• Volume: 12
• Issue: 4
• Pages: 1067-1071
• Publication date: 2011-04-01
• DOI: 10.1021/bm101410q
• EISSN: 1526-4602
• ISSN: 1525-7797
• Language: English
• Keywords: Mass Spectrometry; Quorum Sensing; Polymers; Pseudomonas aeruginosa; Chromatography, High Pressure Liquid; Microscopy, Confocal; Biofilms; Models, Molecular