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Passive control of quorum sensing: prevention of Pseudomonas aeruginosa biofilm formation by imprinted polymers.

Abstract:

Here we present the first molecular imprinted polymer (MIP) that is able to attenuate the biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa through specific sequestration of its signal molecule N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C(12)-AHL). The MIP was rationally designed using computational modeling, and its capacity and specificity and that of a corresponding blank polymer toward signal molecule of P. aeruginosa (3-oxo-C(12)-AHL) and its analogue were...

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Publisher copy:
10.1021/bm101410q

Authors


Piletska, EV More by this author
Stavroulakis, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Whitcombe, MJ More by this author
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Journal:
Biomacromolecules
Volume:
12
Issue:
4
Pages:
1067-1071
Publication date:
2011-04-05
DOI:
EISSN:
1526-4602
ISSN:
1525-7797
URN:
uuid:ff656c0f-bf1b-400f-949e-9320675178c9
Source identifiers:
490708
Local pid:
pubs:490708

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