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The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns.

Abstract:

The adaptive immune system is involved in tumor establishment and aggressiveness. Tumors of the ovaries, an immune-privileged organ, spread via transceolomic routes and rarely to distant organs. This is contrary to tumors of non-immune privileged organs, which often disseminate hematogenously to distant organs. Epigenetics-based immune cell quantification allows direct comparison of the immune status in benign and malignant tissues and in blood. Here, we introduce the "cellular ratio of immun...

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Publication status:
Published

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Publisher copy:
10.4161/epi.26334

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Journal:
Epigenetics : official journal of the DNA Methylation Society
Volume:
8
Issue:
11
Pages:
1226-1235
Publication date:
2013-11-05
DOI:
EISSN:
1559-2308
ISSN:
1559-2294
URN:
uuid:ff57f30e-08ac-4c8b-9ba3-f7110466d260
Source identifiers:
441030
Local pid:
pubs:441030

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