Abnormal function of potassium channels in platelets of patients with Alzheimer's disease.

Journal article

BACKGROUND: Reports of abnormalities of potassium-channel function in various cultured cells of Alzheimer's disease patients led us to attempt to characterise the pharmacological characteristics of the abnormal channel. METHODS: We studied platelets from 14 patients with Alzheimer-type dementia and 14 non-demented controls matched for age and sex. The effects of specific inhibitors of K+ channels on the efflux of rubidium-86 ions, a radioactive analogue of K+, from the platelets were measured...

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Authors: de Silva, H; Aronson, J; Grahame-Smith, D; Jobst, K; Smith, A

• Publication status: Published
• Journal: Lancet
• Volume: 352
• Issue: 9140
• Pages: 1590-1593
• Publication date: 1998-11-01
• DOI: 10.1016/s0140-6736(98)03200-0
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Case-Control Studies; Middle Aged; Hemostatics; Aged; Humans; Thrombin; Apamin; Male; Rubidium; Analysis of Variance; Cells, Cultured; Elapid Venoms; Ionophores; Charybdotoxin; Potassium Channels; Potassium Channel Blockers; Alzheimer Disease; Female; Ionomycin; Drug Interactions