The effects of hippocampal and fimbria-fornix lesions on prepulse inhibition.

Journal article

The present experiments tested the effects of conventional (dorsal aspiration and electrolytic) and excitotoxic (N-methyl-D-aspartate [NMDA]) hippocampal lesions and fimbria-fornix (FF) transection on prepulse inhibition (PPI) of startle response and on open-field activity. Activity was increased by FF transection and by conventional but not excitotoxic hippocampal lesions; complete NMDA lesion increased amphetamine-induced activity. Whereas dorsal hippocampal aspiration lesion disrupted PPI,...

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Authors: Pouzet, B; Feldon, J; Veenman, C; Yee, B; Richmond, M

• Publication status: Published
• Journal: Behavioral neuroscience
• Volume: 113
• Issue: 5
• Pages: 968-981
• Publication date: 1999-10-01
• DOI: 10.1037//0735-7044.113.5.968
• EISSN: 1939-0084
• ISSN: 0735-7044
• Language: English
• Keywords: Rats, Wistar; Startle Reaction; Acoustic Stimulation; Fornix, Brain; Apomorphine; Inhibition (Psychology); Hippocampus; Animals; Dopamine Uptake Inhibitors; Male; Suction; Electric Stimulation; N-Methylaspartate; Motor Activity; Amphetamine; Excitatory Amino Acid Agonists; Rats; Dopamine Agonists