Chromatin regulation by BAF170 controls cerebral cortical size and thickness.

Journal article

Increased cortical size is essential to the enhanced intellectual capacity of primates during mammalian evolution. The mechanisms that control cortical size are largely unknown. Here, we show that mammalian BAF170, a subunit of the chromatin remodeling complex mSWI/SNF, is an intrinsic factor that controls cortical size. We find that conditional deletion of BAF170 promotes indirect neurogenesis by increasing the pool of intermediate progenitors (IPs) and results in an enlarged cortex, whereas...

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Authors: Tuoc, T; Boretius, S; Sansom, S; Pitulescu, M; Frahm, J

• Publication status: Published
• Journal: Developmental cell
• Volume: 25
• Issue: 3
• Pages: 256-269
• Publication date: 2013-05-01
• DOI: 10.1016/j.devcel.2013.04.005
• EISSN: 1878-1551
• ISSN: 1534-5807
• Language: English
• Keywords: Protein Binding; Female; Humans; Chromatin; Nuclear Proteins; Promoter Regions, Genetic; Neurons; Organ Size; Cerebral Cortex; Eye Proteins; Homeodomain Proteins; Paired Box Transcription Factors; Transcription Factors; Epigenesis, Genetic; Chromatin Assembly and Disassembly; Histones; Male; Animals; Hela Cells; Mice, Transgenic; Neurogenesis; Multiprotein Complexes; DNA Methylation; Protein Interaction Mapping; Mice; Repressor Proteins