- Abstract:
- A series of potential UDP-sugar mimics were readily synthesised by copper(I) catalysed modified Huisgen cycloaddition of the corresponding alpha-propargyl glycosides with 5-azido uridine in aqueous solution. None of the compounds accessed displayed significant inhibitory activity at concentrations of up to 4.5mM in an assay against bovine milk beta-1,4-galactosyltransferase.
- Publication status:
- Published
- Publisher copy:
- 10.1016/j.carres.2009.01.001
-
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- Journal:
- Carbohydrate research
- Volume:
- 344
- Issue:
- 5
- Pages:
- 586-591
- Publication date:
- 2009-03-05
- DOI:
- EISSN:
-
1873-426X
- ISSN:
-
0008-6215
- URN:
-
uuid:ff4f780d-a35e-4185-b50c-f5b4ec82f993
- Source identifiers:
-
101110
- Local pid:
- pubs:101110
- Copyright date:
- 2009
Journal article
Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors.
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