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Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors.

Abstract:
A series of potential UDP-sugar mimics were readily synthesised by copper(I) catalysed modified Huisgen cycloaddition of the corresponding alpha-propargyl glycosides with 5-azido uridine in aqueous solution. None of the compounds accessed displayed significant inhibitory activity at concentrations of up to 4.5mM in an assay against bovine milk beta-1,4-galactosyltransferase.
Publication status:
Published

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Authors


Butters, TD More by this author
Wilkinson, BL More by this author
Fairbanks, AJ More by this author
Journal:
Carbohydrate research
Volume:
344
Issue:
5
Pages:
586-591
Publication date:
2009-03-05
DOI:
EISSN:
1873-426X
ISSN:
0008-6215
URN:
uuid:ff4f780d-a35e-4185-b50c-f5b4ec82f993
Source identifiers:
101110
Local pid:
pubs:101110

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