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A method for quantifying cellular uptake of fluorescently labeled siRNA.

Abstract:

Efficient intracellular delivery of siRNA is a significant hurdle to its therapeutic success. For biological studies on the efficiency of carrier-mediated uptake of siRNA, quantitative determination of the amount of internalized siRNA is required. In this study, when the apparent uptake of fluorescently labeled siRNA, formulated in different lipo- and polyplexes, was examined using different techniques, major differences were observed. Additional experiments showed that these differences coul...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
148
Issue:
1
Pages:
106-109
Publication date:
2010-11-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:ff4cbe3d-2573-4789-acf6-ce4b65a9a83b
Source identifiers:
345858
Local pid:
pubs:345858

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