Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation.

Journal article

A partially converted, biodegradable coralline hydroxyapatite/calcium carbonate (CHACC) composite comprising a coral calcium carbonate scaffold enveloped by a thin layer of hydroxyapatite was used in the present study. The CHACC was characterized using powder x-ray diffraction, scanning electron microscopy and energy dispersive x-ray spectroscopy. The ability of the CHACC to promote conductive osteogenesis was assessed in vitro using human mesenchymal stem cells (hMSCs) and in vivo using an i...

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Authors: Fu, K; Xu, Q; Czernuszka, J; Triffitt, J; Xia, Z

• Publication status: Published
• Publisher: Institute of Physics Publishing
• Journal: Biomedical materials (Bristol, England)
• Volume: 8
• Issue: 6
• Pages: 065007
• Publication date: 2013-12-01
• DOI: 10.1088/1748-6041/8/6/065007
• EISSN: 1748-605X
• ISSN: 1748-6041
• Language: English
• Keywords: Bone Neoplasms; Calcium Carbonate; Osteogenesis; Powder Diffraction; Humans; Osteochondroma; Fibrous Dysplasia of Bone; Bone Substitutes; Animals; Microscopy, Electron, Scanning; Female; Tissue Scaffolds; Osseointegration; Hydroxyapatites; Male; Ceramics; Absorbable Implants; Spectrometry, X-Ray Emission; Adolescent; Mesenchymal Stromal Cells; Mice, SCID; Materials Testing; Mice; Cell Differentiation; Cell Proliferation