Cleaning up in the endoplasmic reticulum: ubiquitin in charge.

Journal article

The eukaryotic endoplasmic reticulum (ER) maintains protein homeostasis by eliminating unwanted proteins through the evolutionarily conserved ER-associated degradation (ERAD) pathway. During ERAD, maturation-defective and surplus polypeptides are evicted from the ER lumen and/or lipid bilayer through the process of retrotranslocation and ultimately degraded by the proteasome. An integral facet of the ERAD mechanism is the ubiquitin system, composed of the ubiquitin modifier and the factors fo...

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Authors: Christianson, J; Ye, Y

• Publication status: Published
• Journal: Nature structural and molecular biology
• Volume: 21
• Issue: 4
• Pages: 325-335
• Publication date: 2014-04-01
• DOI: 10.1038/nsmb.2793
• EISSN: 1545-9985
• ISSN: 1545-9993
• Language: English
• Keywords: Homeostasis; Proteolysis; Proteasome Endopeptidase Complex; Animals; Endoplasmic Reticulum; Protein Folding; Ubiquitin-Specific Proteases; Ubiquitins; Models, Biological; Proteins; Ubiquitin