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Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation

Abstract:

The cytokine IFN-γ is a critical regulator of immune system development and function. Almost all leukocytes express the receptor for IFN-γ, yet each cell type elicits a different response to this cytokine. Cell type-specific effects of IFN-γ make it difficult to predict the outcomes of the systemic IFN-γ blockade and limit its clinical application, despite many years of research. To better understand the cell–cell interactions and cofactors that specify IFN-γ functions, we focused on the func...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1073/pnas.1804556115

Authors


Krummel, MF More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Oxford college:
Green Templeton College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Oxford college:
St Hugh's College
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Funding agency for:
Mazet, J
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Funding agency for:
Gerard, A
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
45
Pages:
11585-11590
Publication date:
2018-10-22
Acceptance date:
2018-10-22
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:933808
URN:
uri:ff3a9c55-7956-4628-98ec-255128b37271
UUID:
uuid:ff3a9c55-7956-4628-98ec-255128b37271
Local pid:
pubs:933808

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