Mechanisms to explain the reverse perivascular transport of solutes out of the brain.

Journal article

Experimental studies and observations in the human brain indicate that interstitial fluid and solutes, such as amyloid-beta (Abeta), are eliminated from grey matter of the brain along pericapillary and periarterial pathways. It is unclear, however, what constitutes the motive force for such transport within blood vessel walls, which is in the opposite direction to blood flow. In this paper the potential for global pressure differences to achieve such transport are considered. A mathematical m...

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Authors: Schley, D; Carare-Nnadi, R; Please, C; Perry, V; Weller, R

• Publication status: Published
• Journal: Journal of theoretical biology
• Volume: 238
• Issue: 4
• Pages: 962-974
• Publication date: 2006-02-01
• DOI: 10.1016/j.jtbi.2005.07.005
• EISSN: 1095-8541
• ISSN: 0022-5193
• Language: English
• Keywords: Amyloid beta-Peptides; Elasticity; Cerebral Arteries; Biological Transport, Active; Extracellular Fluid; Pulsatile Flow; Cerebrovascular Circulation; Brain; Humans; Models, Neurological