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Mechanisms to explain the reverse perivascular transport of solutes out of the brain.

Abstract:

Experimental studies and observations in the human brain indicate that interstitial fluid and solutes, such as amyloid-beta (Abeta), are eliminated from grey matter of the brain along pericapillary and periarterial pathways. It is unclear, however, what constitutes the motive force for such transport within blood vessel walls, which is in the opposite direction to blood flow. In this paper the potential for global pressure differences to achieve such transport are considered. A mathematical m...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2005.07.005

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
238
Issue:
4
Pages:
962-974
Publication date:
2006-02-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:ff392179-27be-4a5a-949d-61c7454effc0
Source identifiers:
357201
Local pid:
pubs:357201

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