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Journal article

Structural and functional characterization of the human protein kinase ASK1.

Abstract:

Apoptosis signal-regulating kinase 1 (ASK1) plays an essential role in stress and immune response and has been linked to the development of several diseases. Here, we present the structure of the human ASK1 catalytic domain in complex with staurosporine. Analytical ultracentrifugation (AUC) and crystallographic analysis showed that ASK1 forms a tight dimer (K(d) approximately 0.2 microM) interacting in a head-to-tail fashion. We found that the ASK1 phosphorylation motifs differ from known ASK...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2007.08.011

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Structure (London, England : 1993)
Volume:
15
Issue:
10
Pages:
1215-1226
Publication date:
2007-10-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:ff380bc2-735e-4ac6-bba3-61c79974822c
Source identifiers:
34007
Local pid:
pubs:34007

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