Journal article icon

Journal article

Structural and functional characterization of the human protein kinase ASK1.

Abstract:

Apoptosis signal-regulating kinase 1 (ASK1) plays an essential role in stress and immune response and has been linked to the development of several diseases. Here, we present the structure of the human ASK1 catalytic domain in complex with staurosporine. Analytical ultracentrifugation (AUC) and crystallographic analysis showed that ASK1 forms a tight dimer (K(d) approximately 0.2 microM) interacting in a head-to-tail fashion. We found that the ASK1 phosphorylation motifs differ from known ASK...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.str.2007.08.011

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Expand authors...
Journal:
Structure (London, England : 1993)
Volume:
15
Issue:
10
Pages:
1215-1226
Publication date:
2007-10-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Source identifiers:
34007

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP