Journal article icon

Journal article

The acute cardiovascular actions of intravenous thyrotrophin releasing hormone (TRH) in man are mediated by non-catecholaminergic mechanisms.

Abstract:

1. Intravenous bolus doses of thyrotrophin releasing hormone (TRH, 50-1000 micrograms) caused statistically significant, non-dose dependent and transient rises in blood pressure, heart rate and plasma catecholamines in healthy young males. 2. Mean peak incremental rises in systolic blood pressure (mean +/- s.e. mean) following 50, 200 and 500 micrograms TRH were 14.3 +/- 2.9 mmHg, 15.7 +/- 3.2 mmHg and 17.1 +/- 3.9 mmHg respectively (all P < 0.05 vs placebo). Mean incremental rises in hear...

Expand abstract
Publication status:
Published

Actions


Authors


Bouloux, PM More by this author
Corsello, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
British journal of clinical pharmacology
Volume:
42
Issue:
2
Pages:
225-232
Publication date:
1996-08-05
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:ff360e90-acf8-4b72-adf2-38e23ad9374b
Source identifiers:
138240
Local pid:
pubs:138240

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP