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Journal article

Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.

Abstract:
L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian alpha-glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast alpha-glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition.
Publication status:
Published

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Publisher copy:
10.1039/b406035k

Authors


Butters, TD More by this author
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Journal:
Chemical communications (Cambridge, England)
Issue:
17
Pages:
1936-1937
Publication date:
2004-09-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:ff31bc38-ff7d-473e-9c49-5e7d4afe5c49
Source identifiers:
39208
Local pid:
pubs:39208

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