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Selectivity and permeation of alkali metal ions in K+-channels.

Abstract:

Ion conduction in K(+)-channels is usually described in terms of concerted movements of K(+) progressing in a single file through a narrow pore. Permeation is driven by an incoming ion knocking on those ions already inside the protein. A fine-tuned balance between high-affinity binding and electrostatic repulsive forces between permeant ions is needed to achieve efficient conduction. While K(+)-channels are known to be highly selective for K(+) over Na(+), some K(+) channels conduct Na(+) in ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2011.04.043

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Journal:
Journal of molecular biology
Volume:
409
Issue:
5
Pages:
867-878
Publication date:
2011-06-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:ff1fc3aa-939c-4781-ab0f-083aa18cde5d
Source identifiers:
138814
Local pid:
pubs:138814

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