Inhibition of nitric oxide production exacerbates chronic ocular toxoplasmosis.

Journal article

There is considerable controversy as to the roles of parasite proliferation and the inflammatory response in destruction of the retina during Toxoplasma gondii infection. A murine model was used to investigate the role of nitric oxide in pathogenesis of chronic ocular toxoplasmosis. Increased quantities of messenger RNA (mRNA) transcripts for iNOS were detected in the eyes of chronically infected C57BL/6 mice compared with noninfected control mice. Inhibition of nitric oxide (NO) by the addit...

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Authors: Roberts, F; Roberts, C; Ferguson, D; McLeod, R

• Publication status: Published
• Journal: Parasite immunology
• Volume: 22
• Issue: 1
• Pages: 1-5
• Publication date: 2000-01-01
• DOI: 10.1046/j.1365-3024.2000.00259.x
• EISSN: 1365-3024
• ISSN: 0141-9838
• Language: English
• Keywords: Nitric Oxide Synthase; Toxoplasmosis, Ocular; Nitric Oxide Synthase Type II; Chronic Disease; Nitric Oxide; Mice, Inbred C57BL; Toxoplasmosis, Animal; Mice; NG-Nitroarginine Methyl Ester; RNA, Messenger; Animals