Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence.

Journal article

Anti-inflammatory effects of glucocorticoids (GCs) are partly mediated by up-regulation of DUSP1 (dual specificity phosphatase 1), which dephosphorylates and inactivates mitogen-activated protein kinases. We identified putative GC-responsive regions containing GC receptor (GR) binding site consensus sequences that are well conserved between human and mouse DUSP1 loci in position, orientation, and sequence (at least 11 of 15 positions identical) and lie within regions of extended sequence cons...

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Authors: Tchen, C; Martins, JR; Paktiawal, N; Perelli, R; Saklatvala, J

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 285
• Issue: 4
• Pages: 2642-2652
• Publication date: 2010-01-01
• DOI: 10.1074/jbc.m109.037309
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Cercopithecus aethiops; Humans; Dual Specificity Phosphatase 1; Dexamethasone; Promoter Regions, Genetic; Response Elements; Base Sequence; Species Specificity; Dimerization; Mice; Animals; Glucocorticoids; Hela Cells; Evolution, Molecular; COS Cells; Fibroblasts; Transcriptional Activation; Mutagenesis, Site-Directed; Receptors, Glucocorticoid; Molecular Sequence Data