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Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

Abstract:

The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. However, a considerable proportion of RA patients are refractory to LEF. Here, we investigated lapachol (LAP), a natural naphthoquinone, as a potential DHODH inhibitor and addressed its immunosuppressive properties.Molecular flexible docking studies and bioactivity as...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13075-017-1236-x

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Role:
Author
ORCID:
0000-0001-5465-5238
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Grant:
2009/54014-7, 2011/1967-0, 2012/25075-0, 2014/50265-3, 2012/20990-2, 2013/08216-2
Publisher:
BioMed Central Publisher's website
Journal:
Arthritis Research & Therapy Journal website
Volume:
19
Pages:
Article number 47
Publication date:
2017-03-07
Acceptance date:
2017-01-13
DOI:
ISSN:
1478-6362 and 1478-6354
Pubs id:
pubs:687570
URN:
uri:ff15470e-424a-4f51-9340-d3f5e03a282f
UUID:
uuid:ff15470e-424a-4f51-9340-d3f5e03a282f
Local pid:
pubs:687570

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