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Journal article

Intrathymic delivery of plasmid-encoding endoplasmic reticulum signal-sequence-deleted MHC class I alloantigen can induce long-term allograft survival.

Abstract:

Intrathymic (IT) delivery of donor alloantigen is a potent strategy to induce operational tolerance. In this study we determined whether this effect was dependent on direct allorecognition of the tolerogen. Ten microgrammes of plasmid, encoding either the wildtype major histocompatibility complex (MHC) class I molecule K(b) or a truncated form in which the signal sequence for translocation into the endoplasmic reticulum was deleted, preventing cell surface expression and direct allorecognitio...

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Publication status:
Published

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Publisher copy:
10.1007/s00147-004-0741-4

Authors


Spriewald, BM More by this author
Ensminger, SM More by this author
Jenkins, S More by this author
Morris, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
Transplant international : official journal of the European Society for Organ Transplantation
Volume:
17
Issue:
8
Pages:
458-462
Publication date:
2004-09-05
DOI:
EISSN:
1432-2277
ISSN:
0934-0874
URN:
uuid:ff11cb61-7e79-4021-9f5f-e230dd4e4401
Source identifiers:
135955
Local pid:
pubs:135955

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