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Masked antisense: a molecular configuration for discriminating similar RNA targets.

Abstract:

Antisense technology has great potential for the control of RNA expression, but there remain few successful applications of the technology. Expressed antisense RNA can effectively down-regulate expression of a gene over long periods, but cannot differentiate partly identical sequences, such as the mRNA of fusion genes or those with point mutants. We have designed a structured form of expressed antisense, which can discriminate between highly similar mRNA molecules. These 'masked' antisense RN...

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Publisher copy:
10.1093/embo-reports/kvd003

Authors


Stocks, MR More by this author
Rabbitts, TH More by this author
Journal:
EMBO reports
Volume:
1
Issue:
1
Pages:
59-64
Publication date:
2000-07-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:ff0b3fbf-21c9-4145-a200-7f97fc937095
Source identifiers:
324299
Local pid:
pubs:324299

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