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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

Abstract:

Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ciliogenesis and interferes with the cohesion of duplicated centrosomes. We show here that centrosomal deficits mediated by pathogenic LRRK2 can also be observed in patient-derived iPS cells, and we have used transiently transfected cell lines to identify the underlying mecha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.isci.2022.104476

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Publisher:
Elsevier
Journal:
iScience More from this journal
Volume:
25
Issue:
6
Article number:
104476
Publication date:
2022-05-30
Acceptance date:
2022-05-20
DOI:
EISSN:
2589-0042
ISSN:
2589-0042
Pmid:
35721463
Language:
English
Keywords:
Pubs id:
1264781
Local pid:
pubs:1264781
Deposit date:
2023-01-09

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