Dynamics of killer T cell inflation in viral infections.

Journal article

Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as...

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Authors: Wodarz, D; Sierro, S; Klenerman, P

• Publication status: Published
• Journal: Journal of the Royal Society, Interface / the Royal Society
• Volume: 4
• Issue: 14
• Pages: 533-543
• Publication date: 2007-06-01
• DOI: 10.1098/rsif.2006.0195
• EISSN: 1742-5662
• ISSN: 1742-5689
• Language: English
• Keywords: T-Lymphocytes, Cytotoxic; Humans; Animals; Herpesviridae Infections; Muromegalovirus; Mice, Inbred C57BL; Virus Diseases; Killer Cells, Natural; Mice; Models, Immunological; Immunologic Memory