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CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPα1

Abstract:

The rat OX41 antigen is a cell surface protein containing three immunoglobulin superfamily domains and intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM). It is a homologue of the human signal-regulatory protein (SIRP) also known as SHPS-1, BIT or MFR. Cell activation-induced phosphorylation of the intracellular ITIM motifs induces association with the tyrosine phosphatases SHP-1 and SHP-2. To identify the physiological OX41 ligand, recombinant OX41-CD4d3+4 fusion protein wa...

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Authors


Vernon-Wilson, EF More by this author
Willis, AC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Simmons, DL More by this author
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Journal:
European Journal of Immunology
Volume:
30
Issue:
8
Pages:
2130-2137
Publication date:
2000
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:ff047539-7332-4fd6-be4e-060ea3fefd4c
Source identifiers:
171873
Local pid:
pubs:171873

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