Elevated striatal dopamine function linked to prodromal signs of schizophrenia.

Journal article

CONTEXT: A major limitation on the development of biomarkers and novel interventions for schizophrenia is that its pathogenesis is unknown. Although elevated striatal dopamine activity is thought to be fundamental to schizophrenia, it is unclear when this neurochemical abnormality develops in relation to the onset of illness and how this relates to the symptoms and neurocognitive impairment seen in individuals with prodromal symptoms of schizophrenia. OBJECTIVES: To determine whether striatal...

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Authors: Howes, O; Montgomery, A; Asselin, M; Murray, R; Valli, I

• Journal: Archives of general psychiatry
• Volume: 66
• Issue: 1
• Pages: 13-20
• Publication date: 2009-01-01
• DOI: 10.1001/archgenpsychiatry.2008.514
• EISSN: 1538-3636
• ISSN: 0003-990X
• Language: English
• Keywords: Risk Factors; Schizophrenia; Schizotypal Personality Disorder; Dihydroxyphenylalanine; Cognition Disorders; Female; Neuropsychological Tests; Dopamine; Adult; Psychiatric Status Rating Scales; Male; Brain Mapping; Reference Values; Young Adult; Positron-Emission Tomography; Humans; Dominance, Cerebral; Diagnostic and Statistical Manual of Mental Disorders; Image Processing, Computer-Assisted; Corpus Striatum