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The effects of APOE on the functional architecture of the resting brain.

Abstract:

There is a well-established association between APOE genotype and the risk of developing Alzheimer's disease (AD). Relative to individuals with the common ε3/ε3 genotype, carriers of the ε4 allele are at increased risk of developing AD, while carriers of the ε2 allele appear to be protected against the disease. However, we recently reported that in a sample of cognitively healthy adults, both ε4 and ε2 carriers showed nearly identical changes in the pattern of fMRI activity during memory and ...

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Publication status:
Published

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Authors


Trachtenberg, AJ More by this author
Filippini, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
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Journal:
NeuroImage
Volume:
59
Issue:
1
Pages:
565-572
Publication date:
2012-01-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:fefc175c-65fa-4aa3-911d-c2b4a4b65c9b
Source identifiers:
193010
Local pid:
pubs:193010

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