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The gradual onset brain death model: a relevant model to study organ donation and its consequences on the outcome after transplantation.

Abstract:

Organs used for transplantation are usually derived from heart-beating brain dead donors. However, brain death is known to have negative effects on donor organ quality, previously studied using a difficult to control sudden onset experimental model. We have now developed a reproducible gradual onset brain death model in rats without requiring inotropic support. Fisher inbred rats weighing 260-300 g were used. Brain death was induced by a gradual inflation of a subdurally placed balloon cathet...

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Publication status:
Published

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Publisher copy:
10.1258/002367707781282848

Authors


Kolkert, JL More by this author
't Hart, NA More by this author
van Dijk, A More by this author
Ottens, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
Laboratory animals
Volume:
41
Issue:
3
Pages:
363-371
Publication date:
2007-07-05
DOI:
EISSN:
1758-1117
ISSN:
0023-6772
URN:
uuid:fef7cd9b-af22-492d-b6a0-52eb74bb2254
Source identifiers:
190853
Local pid:
pubs:190853

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