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FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.

Abstract:

Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe developmental disorder of verbal communication, involving profound articulation deficits, accompanied by linguistic and grammatical impairments. Investigation of the neural basis of this disorder has been limited previously to neuroimaging of affected children and adults. The discovery of the gene responsible, FOXP2, offers a unique opportunity to explore the relevant neural mechanisms from a molecula...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awg247

Authors


Gerrelli, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Brain : a journal of neurology
Volume:
126
Issue:
Pt 11
Pages:
2455-2462
Publication date:
2003-11-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:fef62ab1-61e1-4d6f-8a72-6fa3752affd1
Source identifiers:
38832
Local pid:
pubs:38832

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