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Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue.

Abstract:

PPARalpha-deficiency in mice fed a high-carbohydrate, low-cholesterol diet was associated with a decreased weight of epididymal adipose tissue and an increased concentration of adipose tissue cholesterol. Consumption of a high (2% w/w) cholesterol diet resulted in a further increase in the concentration of cholesterol and a further decrease in epididymal fat pad weight in PPARalpha-null mice, but had no effect in the wild-type. These reductions in fat pad weight were associated with an increa...

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Publication status:
Published

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Authors


Knight, BL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Gibbons, GF More by this author
Journal:
Biochimica et biophysica acta
Volume:
1734
Issue:
3
Pages:
259-268
Publication date:
2005-06-05
DOI:
ISSN:
0006-3002
URN:
uuid:fede3b44-4c07-4b10-87dd-f97f5b0cccb8
Source identifiers:
13674
Local pid:
pubs:13674

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