Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue.

Journal article

PPARalpha-deficiency in mice fed a high-carbohydrate, low-cholesterol diet was associated with a decreased weight of epididymal adipose tissue and an increased concentration of adipose tissue cholesterol. Consumption of a high (2% w/w) cholesterol diet resulted in a further increase in the concentration of cholesterol and a further decrease in epididymal fat pad weight in PPARalpha-null mice, but had no effect in the wild-type. These reductions in fat pad weight were associated with an increa...

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Authors: Islam, K; Knight, B; Frayn, K; Patel, D; Gibbons, G

• Publication status: Published
• Journal: Biochimica et biophysica acta
• Volume: 1734
• Issue: 3
• Pages: 259-268
• Publication date: 2005-06-01
• DOI: 10.1016/j.bbalip.2005.03.009
• ISSN: 0006-3002
• Language: English
• Keywords: Cholesterol, Dietary; Receptors, Cytoplasmic and Nuclear; Lipid Metabolism; Organ Size; Fatty Acids; Mice, Knockout; Sterol Regulatory Element Binding Protein 2; Adipose Tissue; Lipids; Epididymis; Mice; Male; Animals; Gene Expression; DNA-Binding Proteins; PPAR alpha; Cholesterol; Transcription Factors; Liver