Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling.

Journal article

OBJECTIVES: The purpose of this study was to examine whether endogenous estrogen deficiency induced by ovariectomy affects chronic left ventricular dysfunction post-myocardial infarction (MI). BACKGROUND: Epidemiologic findings suggest that mortality of postmenopausal women is increased after MI, but the underlying mechanisms are unknown. METHODS: Rats were either not ovariectomized (non-OVX), ovariectomized (OVX) or ovariectomized and treated with subcutaneous 17-beta-estradiol (E2) pellets ...

Expand abstract

Authors: Hügel, S; Reincke, M; Strömer, H; Winning, J; Horn, M

• Journal: Journal of the American College of Cardiology
• Volume: 34
• Issue: 5
• Pages: 1427-1434
• Publication date: 1999-11-01
• DOI: 10.1016/s0735-1097(99)00368-x
• EISSN: 1558-3597
• ISSN: 0735-1097
• Language: English
• Keywords: Disease Models, Animal; Evaluation Studies as Topic; Random Allocation; Animals; Female; Hemodynamics; Echocardiography, Doppler; Rats; Ventricular Remodeling; Myocardial Infarction; Rats, Wistar; Estrogens