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Journal article

Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.

Abstract:

Lys101Glu is a drug resistance mutation in reverse transcriptase clinically observed in HIV-1 from infected patients treated with the non-nucleoside inhibitor (NNRTI) drugs nevirapine and efavirenz. In contrast to many NNRTI resistance mutations, Lys101(p66 subunit) is positioned at the surface of the NNRTI pocket where it interacts across the reverse transcriptase (RT) subunit interface with Glu138(p51 subunit). However, nevirapine contacts Lys101 and Glu138 only indirectly, via water molecu...

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Publication status:
Published

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Journal:
FEBS journal More from this journal
Volume:
273
Issue:
16
Pages:
3850-3860
Publication date:
2006-08-01
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
Language:
English
Keywords:
Pubs id:
pubs:72637
UUID:
uuid:fec61468-af50-42a7-9ae2-67421d9be965
Local pid:
pubs:72637
Source identifiers:
72637
Deposit date:
2012-12-19

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