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Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections

Abstract:

Opisthorchiasis, caused by the food-borne trematode Opisthorchis viverrini, affects more than 8 million people in Southeast Asia. In the framework of a phase 2b clinical trial conducted in Lao PDR, pharmacokinetic samples from 125 adult and adolescent O. viverrini patients treated with 400 mg tribendimidine were obtained following the design of an sparse sampling scheme at 20 min, 2, 7.75, 8 and 30 h after treatment, using dried blood spot sampling. Pharmacokinetic data for the metabolites dA...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01391-18

Authors


Publisher:
American Society for Microbiology
Journal:
Antimicrobial agents and chemotherapy More from this journal
Publication date:
2019-03-27
Acceptance date:
2019-01-17
DOI:
ISSN:
1098-6596 and 0066-4804
Pmid:
30718244
Language:
English
Keywords:
Pubs id:
pubs:971636
UUID:
uuid:febeda71-c766-4c2f-aec2-e57343b4a3a2
Local pid:
pubs:971636
Source identifiers:
971636
Deposit date:
2019-03-04

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