- Abstract:
-
We use a proof-of-concept experiment and two mathematical models to explore growth-induced tissue buckling, as may occur in colorectal crypt formation. Our experiment reveals how growth of a cultured epithelial monolayer on a thin flexible substrate can cause out-of-plane substrate deflections. We describe this system theoretically using a 'bilayer' model in which a growing cell layer adheres to a thin compressible elastic beam. We compare this with the 'supported-monolayer' model due to Edwa...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s10237-010-0280-0
-
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- Journal:
- Biomechanics and modeling in mechanobiology
- Volume:
- 10
- Issue:
- 6
- Pages:
- 883-900
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1617-7940
- ISSN:
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1617-7959
- URN:
-
uuid:fea92faf-9b66-4350-9e69-a8428d15f1c2
- Source identifiers:
-
199833
- Local pid:
- pubs:199833
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Growth-induced buckling of an epithelial layer.
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