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Journal article

Growth-induced buckling of an epithelial layer.

Abstract:

We use a proof-of-concept experiment and two mathematical models to explore growth-induced tissue buckling, as may occur in colorectal crypt formation. Our experiment reveals how growth of a cultured epithelial monolayer on a thin flexible substrate can cause out-of-plane substrate deflections. We describe this system theoretically using a 'bilayer' model in which a growing cell layer adheres to a thin compressible elastic beam. We compare this with the 'supported-monolayer' model due to Edwa...

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Publication status:
Published

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Publisher copy:
10.1007/s10237-010-0280-0

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Journal:
Biomechanics and modeling in mechanobiology
Volume:
10
Issue:
6
Pages:
883-900
Publication date:
2011-12-05
DOI:
EISSN:
1617-7940
ISSN:
1617-7959
URN:
uuid:fea92faf-9b66-4350-9e69-a8428d15f1c2
Source identifiers:
199833
Local pid:
pubs:199833

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