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Journal article

Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.

Abstract:

Nine different IgG fusion proteins and one non-fusion protein, all containing sequences from the extracellular domain of either of two human TNF receptors, were compared for their ability to bind and inhibit human TNF-alpha or TNF-beta. The fusion proteins differed with respect to TNF receptor type (p55 or p75 TNF receptor), receptor valency (one, two or four receptor domains per molecule), the presence or absence of a CH1 domain in the IgG constant region, and the proportion of the extracell...

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Publication status:
Published

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Publisher copy:
10.1006/cyto.1995.0091

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Cytokine More from this journal
Volume:
7
Issue:
8
Pages:
759-770
Publication date:
1995-11-01
DOI:
EISSN:
1096-0023
ISSN:
1043-4666

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