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An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy thai adults

Abstract:

There is no parenteral formulation of the neuraminidase inhibitor oseltamivir, the most widely used anti-influenza virus drug. Oseltamivir resistance is an increasing problem. Zanamivir is effective against the most prevalent oseltamivir-resistant influenza viruses. A parenteral formulation of zanamivir is in development for the treatment of severe influenza. It is not known if there is any pharmacokinetic interaction between the two drugs. Sixteen healthy Thai adult volunteers were studied i...

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Publisher copy:
10.1128/AAC.00159-11

Authors


Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
55
Issue:
9
Pages:
4050-4057
Publication date:
2011-09-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Pubs id:
pubs:179449
UUID:
uuid:fea61e97-b031-40dd-a453-95605fff2c80
Local pid:
pubs:179449
Source identifiers:
179449
Deposit date:
2012-12-19

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