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A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

Abstract:

Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falciparum lack the efficiency necessary for rapid identification and effective evaluation of new vaccines and drugs, especially targeting late liver-stage development and hypnozoites. Herein we report the development of a 384-well plate culture system using commercially available materia...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-6917-3485
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Role:
Author
ORCID:
0000-0002-9560-5656
More from this funder
Name:
National Institutes of Health
Grant:
BAA-NIAID-DAITNIHAI2013164
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Name:
Medicines for Malaria Venture
More from this funder
Name:
Bill and Melinda Gates Foundation
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
9
Issue:
1
Pages:
1837
Publication date:
2018-05-09
Acceptance date:
2018-04-10
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
29743474
Language:
English
Keywords:
Pubs id:
pubs:848134
UUID:
uuid:fea5cdfe-ecad-4f45-95b9-1b6301e4fef7
Local pid:
pubs:848134
Source identifiers:
848134
Deposit date:
2018-07-12

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