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A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

Abstract:

Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falciparum lack the efficiency necessary for rapid identification and effective evaluation of new vaccines and drugs, especially targeting late liver-stage development and hypnozoites. Herein we report the development of a 384-well plate culture system using commercially available materia...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-04221-9

Authors


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ORCID:
0000-0001-6917-3485
More by this author
ORCID:
0000-0002-9560-5656
Conway, AJ More by this author
Chaumeau, V More by this author
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Bill and Melinda Gates Foundation More from this funder
Medicines for Malaria Venture More from this funder
Georgia Research Alliance More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
1837
Publication date:
2018-05-09
Acceptance date:
2018-04-10
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:848134
URN:
uri:fea5cdfe-ecad-4f45-95b9-1b6301e4fef7
UUID:
uuid:fea5cdfe-ecad-4f45-95b9-1b6301e4fef7
Local pid:
pubs:848134
Language:
English
Keywords:

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