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Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.

Abstract:

The Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G(2) phase. Here, we show that FoxM1 transcriptional activity is kept low during G(1)/S through the action of its N-terminal autoinhibitory domain. We found that cyclin A/cdk complexes are required to phosphorylate and activate FoxM1 during G(2) phase. Deletion of the N-terminal autoinhibitory region of FoxM1 generates a mutant of FoxM1 (DeltaN-FoxM1) that is active throughout the cell cycle and no...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.01710-07

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
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Journal:
Molecular and cellular biology
Volume:
28
Issue:
9
Pages:
3076-3087
Publication date:
2008-05-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:fea0d45e-dbc5-49c1-a182-acea2f2e6fd3
Source identifiers:
384607
Local pid:
pubs:384607

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